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A Bisphosphepine Ligand with Stereogenic Phosphorus Centers for the Practical Synthesis of β‐Aryl‐β‐Amino Acids by Asymmetric Hydrogenation
Author(s) -
Tang Wenjun,
Wang Weimin,
Chi Yongxiang,
Zhang Xumu
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351465
Subject(s) - stereocenter , ligand (biochemistry) , asymmetric hydrogenation , aryl , rhodium , chemistry , catalysis , phosphorus , noyori asymmetric hydrogenation , chiral ligand , combinatorial chemistry , stereochemistry , enantioselective synthesis , organic chemistry , receptor , biochemistry , alkyl
Excellent enantioselectivities and reactivities were observed in the hydrogenation of a variety of methyl ( Z )‐β‐aryl‐β‐(acetylamino)acrylates in the presence of a rhodium catalyst with the chiral ligand binapine (see scheme). This bisbinaphthophosphepine ligand has stereogenic phosphorus centers and shows promise as a powerful ligand for application in the synthesis of chiral β‐aryl‐β‐amino acids by asymmetric hydrogenation.