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A Total Synthesis of Epothilones Using Solid‐Supported Reagents and Scavengers
Author(s) -
Storer R. Ian,
Takemoto Toshiyasu,
Jackson Philip S.,
Ley Steven V.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351413
Subject(s) - epothilones , reagent , chemistry , combinatorial chemistry , organic chemistry
A total synthesis of epothilone C ( 1 ) with concomitant formal synthesis of epothilone A is described, using immobilized reagents and scavengers to effect multistep synthetic transformations and purifications.