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From Rigidity to Conformational Flexibility: Macrocyclic Templates Derived from ansa‐Steroids
Author(s) -
Bäurle Stefan,
Blume Thorsten,
Mengel Anne,
Parchmann Christian,
Skuballa Werner,
Bäsler Siegfried,
Schäfer Martina,
Sülzle Detlev,
WronaMetzinger HansPeter
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351385
Subject(s) - rigidity (electromagnetism) , template , steroid , flexibility (engineering) , structural rigidity , stereochemistry , chemistry , combinatorial chemistry , computer science , materials science , mathematics , combinatorics , biochemistry , programming language , statistics , hormone , composite material
More than a curiosity in the field of steroid derivatives, the 17‐membered macrocycle 1 was obtained from a more rigid ansa‐steroid. Compound 1 serves as a prototype of a template with differentiable functional groups, which can be used in the synthesis of libraries of novel macrocycles.