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Design and Synthesis of Paromomycin‐Related Heterocycle‐Substituted Aminoglycoside Mimetics Based on a Mass Spectrometry RNA‐Binding Assay
Author(s) -
Ding Yili,
Hofstadler Steven A.,
Swayze Eric E.,
Risen Lisa,
Griffey Richard H.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351354
Subject(s) - paromomycin , aminoglycoside , binding affinities , chemistry , affinities , rna , combinatorial chemistry , binding site , stereochemistry , biochemistry , antibiotics , receptor , gene
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin ( 1 ). The A‐ring (shown in red) was replaced with a range of heterocycles. An ESIMS‐based RNA‐binding assay was used to screen the binding affinities of the products.