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Trifluoroacetamides from Amino Alcohols as Nucleophilic Trifluoromethylating Reagents
Author(s) -
Joubert Jérôme,
Roussel Solveig,
Christophe Carole,
Billard Thierry,
Langlois Bernard R.,
Vidal Thierry
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351301
Subject(s) - nucleophile , reagent , chemistry , combinatorial chemistry , organic chemistry , catalysis
Both non‐enolizable and enolizable carbonyl compounds underwent nucleophilic trifluoromethylation by a new family of cheap and efficient trifluoroacetamide reagents derived from vic ‐amino alcohols (see picture). From an ecological and an economic viewpoint these represent a promising alternative to other known trifluoromethylation reagents.