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Immunoglobulin–Polydiacetylene Sol–Gel Nanocomposites as Solid‐State Chromatic Biosensors
Author(s) -
Gill Iqbal,
Ballesteros Antonio
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351290
Subject(s) - siloxane , solid state , polymer , nanocomposite , biosensor , liposome , chromatic scale , sol gel , phospholipid , polymer science , chemistry , nanotechnology , materials science , chemical engineering , optics , organic chemistry , physics , biochemistry , engineering , membrane
Rugged and sensitive chromatic solid‐state materials are obtained by encapsulation of bichromic polydiacetylene‐phospholipid liposomes appended with immunoglobulins in hybrid silica–siloxane sol–gel polymers. The resulting composites undergo dramatic and visible blue‐to‐red color transitions upon exposure to the corresponding antigens (see picture) and have applications as sensors.