The Two Main DNA Lesions 8‐Oxo‐7,8‐dihydroguanine and 2,6‐Diamino‐5‐formamido‐4‐hydroxypyrimidine Exhibit Strongly Different Pairing Properties | Zendy

Ober Matthias | Zendy; Linne Uwe | Zendy; Gierlich Johannes | Zendy; Carell Thomas | Zendy

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The Two Main DNA Lesions 8‐Oxo‐7,8‐dihydroguanine and 2,6‐Diamino‐5‐formamido‐4‐hydroxypyrimidine Exhibit Strongly Different Pairing Properties

Author(s) -

Ober Matthias,

Linne Uwe,

Gierlich Johannes,

Carell Thomas

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200351287

Subject(s) - pairing , lesion , dna , chemistry , base pair , dna damage , oxidative phosphorylation , oxidative damage , stereochemistry , physics , biochemistry , oxidative stress , medicine , pathology , superconductivity , quantum mechanics

A stable analogue ( c FapydGuo) of the major oxidative DNA lesion FapydGuo was prepared. The direct comparison of the pairing properties of the oxidative lesion β‐8‐oxodGuo and β‐ c FapydGuo (see formulae) revealed significant differences in base pairing, indicative of unexpected mutagenic differences.

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