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The Two Main DNA Lesions 8‐Oxo‐7,8‐dihydroguanine and 2,6‐Diamino‐5‐formamido‐4‐hydroxypyrimidine Exhibit Strongly Different Pairing Properties
Author(s) -
Ober Matthias,
Linne Uwe,
Gierlich Johannes,
Carell Thomas
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351287
Subject(s) - pairing , lesion , dna , chemistry , base pair , dna damage , oxidative phosphorylation , oxidative damage , stereochemistry , physics , biochemistry , oxidative stress , medicine , pathology , superconductivity , quantum mechanics
A stable analogue ( c FapydGuo) of the major oxidative DNA lesion FapydGuo was prepared. The direct comparison of the pairing properties of the oxidative lesion β‐8‐oxodGuo and β‐ c FapydGuo (see formulae) revealed significant differences in base pairing, indicative of unexpected mutagenic differences.