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Chiral, Porous, Hybrid Solids for Highly Enantioselective Heterogeneous Asymmetric Hydrogenation of β‐Keto Esters
Author(s) -
Hu Aiguo,
Ngo Helen L.,
Lin Wenbin
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351264
Subject(s) - enantioselective synthesis , catalysis , block (permutation group theory) , zirconium , chemistry , variety (cybernetics) , binap , combinatorial chemistry , organic chemistry , asymmetric hydrogenation , computer science , mathematics , combinatorics , artificial intelligence
Catalytic building blocks : Chiral porous zirconium phosphonates containing Ru‐binap moieties are synthesized by a molecular building‐block approach, and characterized by a variety of techniques. These hybrid solids are used for enantioselective heterogeneous asymmetric hydrogenation of β‐keto esters with ee values of up to 95 % (see picture). Ready tunability of such a molecular building‐block approach promises to lead to useful heterogeneous asymmetric catalysts.