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Enantioselective Alkynylation of Ketones Catalyzed by Zn(Salen) Complexes
Author(s) -
Cozzi Pier Giorgio
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351230
Subject(s) - enantioselective synthesis , stereocenter , catalysis , nucleophile , chemistry , alkynylation , combinatorial chemistry , organic chemistry
The new frontier in asymmetric catalysis is the selective formation of quaternary stereocenters. The enantioselective addition of nucleophiles to ketones is a particular challenge. Readily prepared Zn(salen) complexes promote the straightforward synthesis of tertiary alcohols from commercially available starting materials (see scheme), thus allowing the preparation of functionalizable chiral building blocks in a catalytic enantioselective procedure that shows broad scope.