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A Phosphorane as Supported Acylanion Equivalent: Linker Reagents for Smooth and Versatile CC Coupling Reactions
Author(s) -
Weik Steffen,
Rademann Jörg
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351190
Subject(s) - phosphorane , linker , nucleophile , reagent , chemistry , cleavage (geology) , combinatorial chemistry , stereochemistry , sequence (biology) , computational chemistry , computer science , organic chemistry , catalysis , materials science , programming language , biochemistry , fracture (geology) , composite material
Smoothly linked : Polymer‐supported phosphorane 1 is a C‐nucleophile that can be acylated under mild reaction conditions. Diversely substituted α‐ketocarbonyl and α‐hydroxycarbonyl compounds 2 are furnished following to a reaction sequence including oxidative cleavage of the supported phosphoranes.