Premium
Acetylcholine Recognition by a Deep, Biomimetic Pocket
Author(s) -
Hof Fraser,
Trembleau Laurent,
Ullrich Elke Christine,
Rebek, Jr. Julius
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351174
Subject(s) - acetylcholine , acetylcholinesterase , acetylcholine receptor , molecular recognition , chemistry , choline , cholinergic , enzyme , receptor , biophysics , biochemistry , biology , molecule , organic chemistry , neuroscience , pharmacology
Four negative charges at the entrance of a deep pocket, lined with aromatic residues are the features of a synthetic receptor which shows high affinity for acetylcholine (see picture) and choline in water. The size, shape, and charge recognition elements featured in the natural enzyme acetylcholinesterase are reproduced by the synthetic receptor.