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Novel Ruthenium‐ and Platinum‐Catalyzed Sequential Reactions: Synthesis of Tri‐ and Tetrasubstituted Furans and Pyrroles from Propargylic Alcohols and Ketones
Author(s) -
Nishibayashi Yoshiaki,
Yoshikawa Masato,
Inada Youichi,
Milton Marilyn Daisy,
Hidai Masanobu,
Uemura Sakae
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351170
Subject(s) - catalysis , ruthenium , chemistry , platinum , organic chemistry , ketone , medicinal chemistry
Two cats. in the same pot : The two catalysts [Cp*RuCl(μ 2 ‐SMe) 2 RuCp*Cl] ( 1 ) and PtCl 2 ( 2 ) promote a sequence of catalytic cycles in the same medium. Tri‐ or tetrasubstituted furans or pyrroles are afforded in moderate to good yields with high regioselectivities from the catalyzed reactions of propargylic alcohols with ketones or with ketones and anilines, respectively (see scheme; cats.=catalysts).