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Controlling the Oxygenation Level of Hemoglobin by Using a Synthetic Receptor for 2,3‐Bisphosphoglycerate
Author(s) -
Zhong Zhenlin,
Anslyn Eric V.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351165
Subject(s) - hemoglobin , oxygenation , receptor , chemistry , computational biology , biochemistry , computer science , biology , ecology
A designed synthetic receptor ( 1 ), which has guanidinium groups and a Cu II center, is highly effective and selective for binding 2,3‐bisphosphoglycerate (2,3‐BPG) in physiological media (see picture). The affinity is high enough that the receptor can deprive hemoglobin of available 2,3‐BPG, and thus control the active level of 2,3‐BPG and the related oxygenation level of hemoglobin. Cu=Green, N=blue, C=gray, P=yellow, O=red.