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Catalyst‐Controlled Stereoselective Combinatorial Synthesis
Author(s) -
Tietze Lutz F.,
Rackelmann Nils,
Sekar Govindasamy
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351129
Subject(s) - stereoselectivity , domino , enantiomer , combinatorial chemistry , catalysis , chemistry , combinatorial synthesis , stereoisomerism , enantioselective synthesis , organic chemistry , stereochemistry
Stereochemical diversity as a novel concept in combinatorial chemistry for the synthesis of nonpeptidic biologically active compounds is introduced. As an example, the combination of the hydrogenation of imines in the presence of either enantiomer of a chiral Ru catalyst with a domino reaction led to the targeted construction of 12 of the 16 possible stereoisomers of emetine ( 1 ).