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Generation of Oligopeptides with Homochiral Sequences by Topochemical Reactions within Racemic Crystals of Phenylalanine‐ N ‐carboxyanhydride
Author(s) -
Nery José Geraldo,
Bolbach Gérard,
Weissbuch Isabelle,
Lahav Meir
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351114
Subject(s) - oligopeptide , phenylalanine , monomer , chemistry , solid state , crystallography , stereochemistry , materials science , polymer , peptide , amino acid , organic chemistry , biochemistry
Reactions within crystals : Homochiral oligo(phenylalanine)s (see MALDI‐TOF mass spectrum) were obtained from a racemic monomer by utilizing a “zipperlike” mechanism in the solid state (see packing diagram). By generating such species within crystalline architectures, the formation of oligopeptides of up to 17 units in length is plausible.