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Simple Two‐Step ipso Substitution of Aromatic Carboxylic Acids by Alkyl Halides
Author(s) -
Vorndran Katja,
Linker Torsten
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351087
Subject(s) - alkyl , regioselectivity , substituent , chemistry , reagent , halide , carboxylic acid , substitution (logic) , organic chemistry , aryl , medicinal chemistry , catalysis , computer science , programming language
Methyl‐substituted arenes can be synthesized with high regioselectivity in only two steps through formal exchange of an aromatic carboxylic acid function with an alkyl substituent. The results obtained with toluic acid illustrate that good to very good yields can be obtained from inexpensive reagents (see scheme).