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Palladium( 0 )‐Catalyzed Tandem Cyclization of Allenenes
Author(s) -
Ohno Hiroaki,
Miyamura Kumiko,
Takeoka Yusuke,
Tanaka Tetsuaki
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351011
Subject(s) - tandem , palladium , olefin fiber , chemistry , catalysis , aryl , reactivity (psychology) , iodide , combinatorial chemistry , potassium carbonate , medicinal chemistry , stereochemistry , organic chemistry , alkyl , materials science , medicine , alternative medicine , pathology , composite material
Tri‐ and tetracyclic heterocycles were formed through the tandem cyclization of allenenes 1 upon treatment with an aryl iodide, potassium carbonate, and catalytic [Pd(PPh 3 ) 4 ] (see scheme). The reactivity of the palladium( II ) intermediates could be controlled by substitution (R′) at the olefin terminus (Mts=2,4,6‐trimethylphenylsulfonyl).