Functionality Propagation by Alkylative Oxidation of Cross‐Conjugated Cycloheptadienyl Sulfones | Zendy

Torres Eduardo | Zendy; Chen Yuzhong | Zendy; Kim In Chul | Zendy; Fuchs P. L. | Zendy

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Functionality Propagation by Alkylative Oxidation of Cross‐Conjugated Cycloheptadienyl Sulfones

Author(s) -

Torres Eduardo,

Chen Yuzhong,

Kim In Chul,

Fuchs P. L.

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200350955

Subject(s) - enantiopure drug , sulfone , chemistry , nucleophile , sulfur , conjugated system , sequence (biology) , combinatorial chemistry , methylation , stereochemistry , organic chemistry , catalysis , enantioselective synthesis , dna , biochemistry , polymer

Getting the most out of sulfur . Enantiopure epoxyvinyl sulfone 1 is transformed to syn‐ and anti ‐dienyl sulfones 2 and 3 , respectively, by means of a nucleophilic methylation/sulfenylation/directed elimination reaction sequence. Compound 2 has been converted into termini‐differentiated seven‐carbon polypropionate segments found in five biologically significant natural products.

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