Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross‐Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin | Zendy

Carlomagno Teresa | Zendy; Sánchez Víctor M. | Zendy; Blommers Marcel J. J. | Zendy; Griesinger Christian | Zendy

Premium

Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross‐Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin

Author(s) -

Carlomagno Teresa,

Sánchez Víctor M.,

Blommers Marcel J. J.,

Griesinger Christian

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200350950

Subject(s) - dihedral angle , chemistry , moiety , dipole , crystallography , steric effects , torsion (gastropod) , stereochemistry , pulse sequence , tubulin , microtubule , nuclear magnetic resonance , molecule , organic chemistry , physics , hydrogen bond , medicine , surgery , biology , microbiology and biotechnology

C–C torsion angles in HC‐CCH 3 moieties can be measured by a new NMR experiment based on the measurement of CH–CH dipolar–dipolar cross‐correlated relaxation rates and is demonstrated on a mixture of 13 C‐labeled epothilone ( 1 ) and tubulin. The new pulse sequence is broadly applicable to any HC‐CCH 3 moiety and therefore to a number of amino acid side chains in proteins.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research