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Rational Ligand Design in Constructing Efficient Catalyst Systems for Suzuki–Miyaura Coupling
Author(s) -
Miura Masahiro
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301753
Subject(s) - steric effects , aryl , ligand (biochemistry) , carbene , chemistry , catalysis , combinatorial chemistry , coupling (piping) , coupling reaction , organic chemistry , materials science , biochemistry , alkyl , receptor , metallurgy
Designer ligands : The use of phosphane and N‐heterocyclic carbene ligands allows the Suzuki–Miyaura coupling of sterically encumbered aryl chlorides and bromides to aryl boronic acids with relatively low Pd loadings under mild conditions. Even the very bulky 2,4,6‐triisopropylphenyl group can be employed in the coupling reaction in the presence of an appropriately designed phosphane ligand (for example, see formula).