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Polyamides as Artificial Transcription Factors: Novel Tools for Molecular Medicine?
Author(s) -
Schmitz Katja,
Schepers Ute
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301745
Subject(s) - homeobox , transcription factor , gene , transcription (linguistics) , dna , biology , computational biology , cell , gene expression , genetics , microbiology and biotechnology , linguistics , philosophy
Misregulation of gene expression often leads to severe defects in the development of an organism or to uncontrolled cell growth. Artificial transcription factors can control the expression of the genes concerned to restore normal cell regulation. Dervan and co‐workers have synthesized several DNA‐binding polyamides (see picture: TALE (yellow) is a class of homeobox protein) that show potential for the treatment of diseases such as cancer.