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A Brighter Future for Protein Design
Author(s) -
Tramontano Anna
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301738
Subject(s) - protein design , protein engineering , field (mathematics) , sequence (biology) , computer science , protein structure prediction , computational biology , protein structure , topology (electrical circuits) , engineering , biology , mathematics , genetics , biochemistry , pure mathematics , electrical engineering , enzyme
A deeper understanding of the sequence–structure relationship in proteins has resulted from research in the field of protein design. Recent success in designing a protein with a topology not yet observed in nature (see picture) increases our confidence in computational biology and should open the road to the engineering of molecular machines with specified properties and functions.