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Bigger DNA: New Double Helix with Expanded Size
Author(s) -
Marx Andreas,
Summerer Daniel
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301737
Subject(s) - nucleobase , dna , helix (gastropod) , base pair , pairing , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , chemistry , crystallography , stereochemistry , biophysics , biology , physics , biochemistry , ecology , superconductivity , quantum mechanics , snail
Outsized nucleosides inside: A recent report described the rational design of an artificial DNA double helix (xDNA) with increased diameter. The pairing system is based on nucleobase analogues which maintain the natural Watson–Crick binding sites but have extended aromatic surfaces (see picture, view along DNA and xDNA helices).