Premium
Activation of Carbonyl Compounds by Double Hydrogen Bonding: An Emerging Tool in Asymmetric Catalysis
Author(s) -
Pihko Petri M.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301732
Subject(s) - catalysis , aldol reaction , chemistry , hydrogen bond , hydrogen , carbonyl group , combinatorial chemistry , organic chemistry , stereochemistry , molecule
An exceptionally useful tool in the development of novel chiral catalysts for carbonyl chemistry is the activation of carbonyl groups by double hydrogen bonding (see scheme). A diverse set of reactions such as the asymmetric Diels–Alder, hetero‐Diels–Alder, aldol, and Morita–Baylis–Hillman reactions can be accelerated by such double‐hydrogen‐bonding catalysts.