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Two Birds with One Metallic Stone: Single‐Pot Catalysis of Fundamentally Different Transformations
Author(s) -
Ajamian Alain,
Gleason James L.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301727
Subject(s) - catalysis , carbon fibers , heteroatom , scope (computer science) , transformation (genetics) , nanotechnology , chemistry , materials science , combinatorial chemistry , organic chemistry , computer science , ring (chemistry) , biochemistry , composite number , composite material , gene , programming language
Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal‐catalyzed reactions now covering nearly all areas of carbon–carbon, carbon–hydrogen, and carbon–heteroatom bond formation. For years, the goal was to develop catalysts that were highly selective for a single transformation. However, a promising current area of research is the use of a single catalyst to mediate more than one transformation in a selective manner. Whereas much early work was focused on using a catalyst for several similar transformations, recent investigations have shown that it is also possible to employ a single catalyst for several very different transformations in a single reaction sequence. This Minireview focuses on methods in which the mechanisms of the transformations are fundamentally very different.