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Catalyzed Reactions of Acyl Anion Equivalents
Author(s) -
Johnson Jeffrey S.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301702
Subject(s) - umpolung , aldehyde , benzoin , chemistry , ketone , enantioselective synthesis , imine , organic chemistry , medicinal chemistry , catalysis , nucleophile
More than century after the description of the benzoin condensation, chemists are developing new approaches toward and new reactions involving aldehyde umpolung. This chemistry has been recently expressed in aldehyde/ketone benzoin condensations, aldehyde/imine couplings, and enantioselective benzoin (B) and Stetter (A) reactions (see scheme; M = K, Na, Bu 4 N; Y = S, NR; Z = CH, N; X=alkoxy, alkyl).