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Asymmetric Cycloisomerization of 1,6‐ and 1,7‐Enynes by Transition‐Metal Catalysts
Author(s) -
Fairlamb Ian J. S.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301699
Subject(s) - cycloisomerization , catalysis , transition metal , chemistry , organic chemistry
Highly functionalized carbo‐ and heterocycles can be prepared enantioselectively from simple enynes in transition‐metal‐catalyzed reactions. This versatile, atom‐economic, and environmentally friendly approach has become a mainstay in natural product synthesis. The concise synthesis of (+)‐pilocarpine is one example (see scheme). binap=2,2′‐bis(diphenylphosphanyl)‐1,1′‐binaphthyl), cod=cyclooctadiene, RT=room temperature.