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Re‐Engineering the Genetic Code: Combining Molecular Biology and Organic Chemistry
Author(s) -
van Maarseveen Jan H.,
Back Jaap Willem
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301698
Subject(s) - genetic code , chemistry , nanotechnology , computational biology , materials science , biology , biochemistry , dna
Imagine… if the biomachinery of nature accepted every uncoded amino acid site‐specifically as desired. Spectacular advances in breaking the genetic code to expand the set of amino acids available for protein biosynthesis are highlighted, and examples of the post‐translational chemical modification of proteins containing these nonnatural amino acids are presented (see scheme).