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Chiral Tertiary Alcohols Made By Catalytic Enantioselective Addition of Unreactive Zinc Reagents to Poorly Electrophilic Ketones?
Author(s) -
Ramón Diego J.,
Yus Miguel
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301696
Subject(s) - enantioselective synthesis , stereocenter , chemistry , ketone , reagent , electrophile , nucleophile , zinc , organic chemistry , catalysis , tertiary alcohols , combinatorial chemistry
Ligands that activate both the starting ketone and the zinc reagent are essential in catalyzing enantioselective nucleophilic additions yielding tertiary alcohols [Eq. (1)]. Controlled generation of compounds with such quaternary stereogenic centers is one of the major challenges in synthetic organic chemistry.