Premium
Supramolecular Drug‐Delivery Systems Based on Polymeric Core–Shell Architectures
Author(s) -
Haag Rainer
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301694
Subject(s) - nanocarriers , supramolecular chemistry , shielded cable , endocytosis , drug delivery , nanotechnology , biophysics , chemistry , drug , materials science , cell , computer science , biochemistry , biology , pharmacology , organic chemistry , telecommunications , crystal structure
Hitting the target : Although the cellular uptake of supramolecular nanocarriers by endocytosis is not cell‐specific, a high passive selectivity has been observed in porous tissues, such as tumor tissue. The encapsulated, often toxic, drug is efficiently shielded and can develop its activity by selective release from the nanocarrier upon a shift of the pH value in the tumor tissue or inside the cell (see scheme).