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New Catalytic Approaches in the Stereoselective Friedel–Crafts Alkylation Reaction
Author(s) -
Bandini Marco,
Melloni Alfonso,
UmaniRonchi Achille
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301679
Subject(s) - friedel–crafts reaction , alkylation , stereoselectivity , catalysis , chemistry , organic chemistry , combinatorial chemistry , scope (computer science) , computer science , programming language
After more than 125 years, the Friedel–Crafts alkylation is still one of the most studied and most utilized reactions in organic synthesis. What is the secret of this astonishing success? Perhaps the great versatility in scope and applicability continues to justify its crucial role in the synthesis of more and more complex molecules. However, it has taken more than a century for asymmetric catalytic versions of this reaction to be developed and subsequently extended to a range of aromatic compounds and alkylating agents. Herein we review recent developments in the design and use of catalytic and stereoselective strategies for the alkylation of aromatic systems and synthesis of a wide range of polyfunctionalized enantiomerically enriched compounds.