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Improved Chemical Strategies for the Targeted Therapy of Cancer
Author(s) -
Maison Wolfgang,
Frangioni John V.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301666
Subject(s) - cancer therapy , targeted therapy , cancer , conjugate , medicine , mathematics , mathematical analysis
One of the prerequisites for the successful treatment of cancer is selective or “targeted” therapy. Particularly important in this respect are recent advances in the conjugation of cytotoxic compounds to tumor‐specific targeting molecules (see picture). The current trend is aimed at minimizing the size of the conjugates.