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Increasing the Local Concentration of Drugs by Hydrogel Formation
Author(s) -
Tiller Joerg C.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301647
Subject(s) - vancomycin , drug , pyrene , chemistry , antimicrobial , antibiotics , mechanism (biology) , combinatorial chemistry , pharmacology , bacteria , organic chemistry , biochemistry , medicine , staphylococcus aureus , biology , philosophy , epistemology , genetics
Drugs that gel: The first hydrogel‐forming drug, a pyrene‐derivatized form of the antibiotic vancomycin (see structure), exhibits an 11‐fold higher antimicrobial activity than vancomycin itself. A possible mechanism for this effect and its influence on future drug design are discussed.