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The Total Syntheses of Phorboxazoles—New Classics in Natural Product Synthesis
Author(s) -
Haustedt Lars Ole,
Hartung Ingo V.,
Hoffmann H. M. R.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200301643
Subject(s) - natural product , total synthesis , natural (archaeology) , product (mathematics) , classics , art , chemistry , history , organic chemistry , mathematics , archaeology , geometry
The marine sponge metabolites phorboxazoles A (see structural formula) and B were the targets of several clever total syntheses, whose special features are described in this Highlight. Now that the synthetic entry to these compounds has been cleared, their cytostatic activity can be studied thoroughly in vitro and in vivo.