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Palladium Oxidase Catalysis: Selective Oxidation of Organic Chemicals by Direct Dioxygen‐Coupled Turnover
Author(s) -
Stahl Shan S.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200300630
Subject(s) - palladium , chemistry , catalysis , reactivity (psychology) , benzoquinone , molecular oxygen , substrate (aquarium) , combinatorial chemistry , selectivity , redox , photochemistry , decomposition , catalytic oxidation , oxygen , organic synthesis , organic chemistry , medicine , oceanography , alternative medicine , pathology , geology
Selective aerobic oxidation of organic molecules is a fundamental and practical challenge in modern chemistry. Effective solutions to this problem must overcome the intrinsic reactivity and selectivity challenges posed by the chemistry of molecular oxygen, and they must find application in diverse classes of oxidation reactions. Palladium oxidase catalysis combines the versatility of Pd II ‐mediated oxidation of organic substrates with dioxygen‐coupled oxidation of the reduced palladium catalyst to enable a broad range of selective aerobic oxidation reactions. Recent developments revealed that cocatalysts (e.g. Cu II , polyoxometalates, and benzoquinone) are not essential for efficient oxidation of Pd 0 by molecular oxygen. Oxidatively stable ligands play an important role in these reactions by minimizing catalyst decomposition, promoting the direct reaction between palladium and dioxygen, modulating organic substrate reactivity and permitting asymmetric catalysis.