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Industrial Methods for the Production of Optically Active Intermediates
Author(s) -
Breuer Michael,
Ditrich Klaus,
Habicher Tilo,
Hauer Bernhard,
Keßeler Maria,
Stürmer Rainer,
Zelinski Thomas
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200300599
Subject(s) - chemistry , chemical industry , organic chemistry , biochemical engineering , fine chemical , enantioselective synthesis , amino acid , chemical synthesis , combinatorial chemistry , catalysis , biochemistry , engineering , in vitro
Abstract Enantiomerically pure amino acids, amino alcohols, amines, alcohols, and epoxides play an increasingly important role as intermediates in the pharmaceutical industry and agrochemistry, where both a high degree of purity and large quantities of the compounds are required. The chemical industry has primarily relied upon established chemical methods for the synthesis of these intermediates, but is now turning more and more to enzymatic and biotechnological fermentation processes. For the industrial implementation of many transformations alternative methods are available. The advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.