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Highly Functionalized Organomagnesium Reagents Prepared through Halogen–Metal Exchange
Author(s) -
Knochel Paul,
Dohle Wolfgang,
Gommermann Nina,
Kneisel Florian F.,
Kopp Felix,
Korn Tobias,
Sapountzis Ioannis,
Vu Viet Anh
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200300579
Subject(s) - reagent , chemistry , halogen , group 2 organometallic chemistry , organic chemistry , magnesium , amination , combinatorial chemistry , organic synthesis , nitro , molecule , catalysis , alkyl
Organomagnesium reagents occupy a central position in synthetic organic and organometallic chemistry. Recently, the halogen–magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes. Functional groups such as esters, nitriles, iodides, imines, or even nitro groups can be present in a wide range of aromatic and heterocyclic organomagnesium reagents. Also various highly functionalized alkenyl magnesium species can be prepared. These recent developments as well as new applications of organomagnesium reagents in cross‐coupling reactions and amination reactions will be covered in this Review.