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Structure of a Drug‐Induced DNA T‐Bulge: Implications for DNA Frameshift Mutations
Author(s) -
Colgrave Michelle L.,
Williams Huw E. L.,
Searle Mark S.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200290039
Subject(s) - frameshift mutation , dna , base pair , intercalation (chemistry) , chemistry , stereochemistry , biophysics , a dna , crystallography , mutation , biology , biochemistry , gene , inorganic chemistry
A bulged conformation in which the T3 base is flipped‐out of the helical stack of the novel DNA hairpin H2 allowing complementary pairing downstream of the intercalation site (see picture) is stabilized by binding of the drug nogalamycin. This finding was readily confirmed by detailed analysis of the chemical shift and NOE data.