Stereoselective Total Synthesis of Mucocin, an Antitumor Agent | Zendy

Takahashi Shunya | Zendy; Kubota Akemi | Zendy; Nakata Tadashi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Stereoselective Total Synthesis of Mucocin, an Antitumor Agent

Author(s) -

Takahashi Shunya,

Kubota Akemi,

Nakata Tadashi

Publication year - 2002

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200290038

Subject(s) - desymmetrization , stereoselectivity , chemistry , alkoxy group , alcohol , acrylate , total synthesis , combinatorial chemistry , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , polymer , alkyl , monomer

The THP and THF rings which are regarded as the characteristic structural features of mucocin ( 1 ) were constructed by a SmI 2 ‐induced reductive cyclization of β‐alkoxy acrylate and oxidative cyclization of a homoallyl alcohol, respectively. The key intermediates were synthesized through an efficient desymmetrization of a C 2 ‐symmetric tetraol.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research