Unparalleled Rates for the Activation of Aryl Chlorides and Bromides: Coupling with Amines and Boronic Acids in Minutes at Room Temperature | Zendy

Stambuli James P. | Zendy; Kuwano Ryoichi | Zendy; Hartwig John F. | Zendy

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Unparalleled Rates for the Activation of Aryl Chlorides and Bromides: Coupling with Amines and Boronic Acids in Minutes at Room Temperature

Author(s) -

Stambuli James P.,

Kuwano Ryoichi,

Hartwig John F.

Publication year - 2002

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200290036

Subject(s) - aryl , chemistry , coupling (piping) , boronic acid , combinatorial chemistry , organic chemistry , polymer chemistry , materials science , alkyl , metallurgy

Exceptionally fast oxidative addition of an aryl chloride (or a deactivated aryl bromide) to the active Pd 0 center, which is ligated by sterically demanding phosphanes, occurs during coupling reactions catalyzed by air‐stable Pd I dimers as shown in the scheme. As a result, the reactions of aryl chlorides and bromides with amines and boronic acids at room temperature are complete within a few minutes. 1‐Ad=1‐adamantyl.

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