Premium
An Efficient One‐Pot Enantio‐ and Diastereoselective Synthesis of Heterocycles
Author(s) -
Trost Barry M.,
Machacek Michelle R.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200290019
Subject(s) - catalysis , chemistry , substrate (aquarium) , tsuji–trost reaction , enantioselective synthesis , allylic rearrangement , alkylation , combinatorial chemistry , nitrogen , organic chemistry , stereochemistry , oceanography , geology
Five‐ and six‐membered nitrogen and oxygen heterocycles are accessible from two acyclic precursors in a one‐pot reaction that comprises a Ru‐catalyzed ene–yne addition followed by a Pd‐catalyzed asymmetric allylic alkylation (see scheme). The stereochemistry of the products derives from the catalyst rather than from substrate control using chiral substrates.