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Total Synthesis of (±)‐FR66979
Author(s) -
Ducray Richard,
Ciufolini Marco A.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200290017
Subject(s) - aziridine , total synthesis , transposition (logic) , fragmentation (computing) , stereochemistry , chemistry , biology , computer science , organic chemistry , artificial intelligence , ecology , ring (chemistry)
An unusual fragmentation of aziridine 1 , triggered by a preliminary homo‐Brook transposition is the key step in the total synthesis of the racemate of the antitumor agent FR66979 ( 2 ).