Premium
Facile Construction of N ‐Hydroxybenzazocine: Enantioselective Total Synthesis of (+)‐FR900482
Author(s) -
Suzuki Masashi,
Kambe Mika,
Tokuyama Hidetoshi,
Fukuyama Tohru
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200290016
Subject(s) - enantioselective synthesis , total synthesis , chemistry , stereochemistry , organic chemistry , catalysis
Intramolecular hydroxylamination of ω‐formyl nitrobenzene 1 followed by stereoselective hydroxymethylation led to the formation of N ‐hydroxybenzazocine 2 , a key intermediate in the enantioselective total synthesis of the antitumor antibiotic FR900482 ( 3 ).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom