Premium
Total Synthesis of (±)‐Wortmannin
Author(s) -
Mizutani Takashi,
Honzawa Shinobu,
Tosaki Shinya,
Shibasaki Masakatsu
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200290014
Subject(s) - wortmannin , allylic rearrangement , trimethylsilyl , intramolecular force , scheme (mathematics) , chemistry , computer science , stereochemistry , kinase , medicinal chemistry , phosphatidylinositol , organic chemistry , mathematics , biochemistry , catalysis , mathematical analysis
A potent and specific phosphoinositide 3‐kinase inhibitor (±)‐wortmannin has been achieved through an intramolecular Heck reaction for the construction of an allylic quaternary carbon center and a diosphenol–Claisen rearrangement (see scheme). SEM=2‐(Trimethylsilyl)ethoxymethyl.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom