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A Convenient Procedure for the Palladium‐Catalyzed Cyanation of Aryl Halides
Author(s) -
Sundermeier Mark,
Zapf Alexander,
Beller Matthias
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250778
Subject(s) - cyanation , palladium , aryl , chemistry , catalysis , cyanide , reagent , halide , bromobenzene , bromide , aryl halide , organic chemistry , polymer chemistry , medicinal chemistry , inorganic chemistry , alkyl
A useful source of cyanide for the palladium‐catalyzed cyanation of aryl halides is acetone cyanohydrin (see scheme; dpppe=1,5‐bis(diphenylphosphanyl)pentane, tmeda= N,N,N ′, N ′‐tetramethylethylenediamine). The key to the success of the reaction is the slow dosage of the cyanation reagent to the reaction mixture to prevent the deactivation of the palladium catalyst caused by excess cyanide ions in solution.