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Sequence‐Selective Molecular Recognition between β Sheets
Author(s) -
Nowick James S.,
Chung De Michael
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250750
Subject(s) - sequence (biology) , valine , threonine , peptide , selectivity , molecular recognition , chemistry , peptide sequence , stereochemistry , biochemistry , gene , amino acid , molecule , serine , enzyme , organic chemistry , catalysis
Molecular recognition between peptide β sheets is sequence selective! By simply controlling the placement of two threonine (Thr) or valine (Val) residues, peptides that preferentially form either homodimers or heterodimers with about tenfold selectivity can be generated. The picture shows the structure of a Thr–Val⋅Val–Thr heterodimer.