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Asymmetric Desymmetrization of meso ‐1,2‐Diols by Phosphinite Derivatives of Cinchona Alkaloids
Author(s) -
Mizuta Shinya,
Sadamori Mikito,
Fujimoto Tetsuya,
Yamamoto Iwao
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250719
Subject(s) - desymmetrization , phosphinite , catalysis , chemistry , cinchonine , cinchona alkaloids , cinchona , derivative (finance) , organic chemistry , enantioselective synthesis , business , finance
An effective catalyst for the asymmetric monobenzoylation of meso ‐1,2‐diols was designed—the phosphinite derivative of cinchonine (see formula). In the presence of 30 mol % of this catalyst the monobenzoylated products were obtained with high yields and enantioselectivities.