Premium
Asymmetric Desymmetrization of meso ‐1,2‐Diols by Phosphinite Derivatives of Cinchona Alkaloids
Author(s) -
Mizuta Shinya,
Sadamori Mikito,
Fujimoto Tetsuya,
Yamamoto Iwao
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250719
Subject(s) - desymmetrization , phosphinite , catalysis , chemistry , cinchonine , cinchona alkaloids , cinchona , derivative (finance) , organic chemistry , enantioselective synthesis , business , finance
An effective catalyst for the asymmetric monobenzoylation of meso ‐1,2‐diols was designed—the phosphinite derivative of cinchonine (see formula). In the presence of 30 mol % of this catalyst the monobenzoylated products were obtained with high yields and enantioselectivities.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom