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Enantio‐ and Diastereoselective Ir‐Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives
Author(s) -
Kanayama Takatoshi,
Yoshida Kazumasa,
Miyabe Hideto,
Takemoto Yoshiji
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250654
Subject(s) - enantioselective synthesis , allylic rearrangement , diastereomer , catalysis , chemistry , substitution (logic) , stereochemistry , substitution reaction , base (topology) , combinatorial chemistry , organic chemistry , mathematics , computer science , programming language , mathematical analysis
Simply switching the base employed in the first enantioselective allylic substitutions of diphenylimino glycinate 1 with 2 , which are catalyzed by an Ir complex of chiral phosphite 5 , allows the two branched diastereomers 3 and 4 to be selectively synthesized with little or no formation of linear substitution products.