Enantio‐ and Diastereoselective Ir‐Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives | Zendy

Kanayama Takatoshi | Zendy; Yoshida Kazumasa | Zendy; Miyabe Hideto | Zendy; Takemoto Yoshiji | Zendy

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Enantio‐ and Diastereoselective Ir‐Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives

Author(s) -

Kanayama Takatoshi,

Yoshida Kazumasa,

Miyabe Hideto,

Takemoto Yoshiji

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200250654

Subject(s) - enantioselective synthesis , allylic rearrangement , diastereomer , catalysis , chemistry , substitution (logic) , stereochemistry , substitution reaction , base (topology) , combinatorial chemistry , organic chemistry , mathematics , computer science , programming language , mathematical analysis

Simply switching the base employed in the first enantioselective allylic substitutions of diphenylimino glycinate 1 with 2 , which are catalyzed by an Ir complex of chiral phosphite 5 , allows the two branched diastereomers 3 and 4 to be selectively synthesized with little or no formation of linear substitution products.

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