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Determination of the Configuration of an Archaea Membrane Lipid Containing Cyclopentane Rings by Total Synthesis
Author(s) -
Montenegro Elvira,
Gabler Bert,
Paradies Gesa,
Seemann Matthias,
Helmchen Günter
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250629
Subject(s) - cyclopentane , archaea , membrane , chemistry , glycerol , membrane lipids , total synthesis , diol , organic chemistry , stereochemistry , biochemistry , gene
The fat controller : Thermoacidophilic Archaea possess membranes containing lipids consisting of mixtures of macrocyclic, 72‐membered tetraethers composed of saturated isoprenoid chains linked to glycerol or higher sugars. Lipids of this type form highly stable liposomes and, therefore, are of commercial interest. The configurations of lipids containing cyclopentane units have now been determined by total synthesis of the diol 1 .