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Kinetic Control in Direct α ‐Silyloxy Ketone Synthesis: A New Regiospecific Catalyzed Cross Silyl Benzoin Reaction
Author(s) -
Linghu Xin,
Johnson Jeffrey S.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250554
Subject(s) - benzoin , silylation , ketone , yield (engineering) , adduct , chemistry , catalysis , organic chemistry , materials science , metallurgy
Side‐stepping thermodynamics . In contrast to the traditional benzoin reaction, which can yield a mixture of homo and mixed adducts, only one regioisomer was obtained from the new cyanide‐catalyzed silyl benzoin reaction between acylsilanes and aldehydes (see scheme).
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